A statistical mediation model was developed within a twin design to investigate the etiology of alcohol use disorder (AUD). Unlike conventional statistical mediation models, this biometric mediation model can detect unobserved confounding. Using a sample of 1410 pairs of Norwegian twins, we investigated specific hypotheses that DSM-IV personality-disorder (PD) traits mediate effects of childhood stressful life events (SLEs) on AUD, and that adulthood SLEs mediate effects of PDs on AUD. Models including borderline PD traits indicated unobserved confounding in phenotypic path coefficients, whereas models including antisocial and impulsive traits did not. More than half of the observed effects of childhood SLEs on adulthood AUD were mediated by adulthood antisocial and impulsive traits. Effects of PD traits on AUD 5‒10 years later were direct rather than mediated by adulthood SLEs. The results and the general approach contribute to triangulation of developmental origins for complex behavioral disorders.

中文翻译：

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遗传信息中介模型应用于酒精使用障碍的病因中的压力源和人格障碍特征。

在双胞胎设计中开发了一种统计调解模型，以研究酒精使用障碍（AUD）的病因。与常规统计调解模型不​​同，此生物统计调解模型可以检测到未观察到的混淆。我们使用1410对挪威双胞胎的样本，研究了特定的假设，即DSM-IV人格障碍（PD）特征介导了儿童应激性生活事件（SLE）对AUD的影响，而成年SLE介导了PD对AUD的影响。包括边缘PD特质的模型表明在表型路径系数中没有发现混淆，而包括反社会和冲动特质的模型则没有。观察到的儿童SLE对成年AUD的影响的一半以上是由成年的反社会和冲动性特质介导的。PD性状对AUD 5 ‒ 10年后的影响是直接的，而不是由成年SLE介导的。结果和一般方法有助于对复杂行为障碍的起源进行三角剖分。