Mannose binding lectin 2 (MBL2) is one of the pattern-recognition soluble receptors and is responsible for complement activation via the lectin pathway, so it plays an important role in kidney transplantation.

The aim of the study was to examine the association between MBL2 gene polymorphisms and acute rejection of the kidney allograft. This study enrolled 266 Caucasian deceased-donor renal transplant recipients – 69 with diagnosed acute graft rejection, 197 with stable graft function.

A 969 bp DNA fragment, from chromosome 10, including promoter region and exon 1 of MBL2 gene was sequenced. The DNA fragment obtained contained 122 SNPs accordingly to the NCBI dbSNP database. Of this number only nine showed variation within our population (rs36014597, rs5030737, rs1800450, rs7095891, rs11003123, rs7096206, rs7084554, rs11003124, rs11003125), and only these were subjected to further analysis.

Among the studied polymorphisms in the MBL2 gene only rs1800450 polymorphism was statistically significantly associated with kidney allograft rejection. The AA genotype was significantly associated with an increased risk of acute kidney allograft rejection. (AA vs GA+GG: OR=9.29 (95%CI: 1.83–47.17), p=0.005).

The results of our study indicate that MBL2 gene rs1800450 polymorphism may be associated with the risk of acute kidney allograft rejection. The AA genotype, associated with lower MBL2 expression, may be associated with an increased risk of acute kidney allograft rejection.

甘露糖结合凝集素2（MBL2）是模式识别可溶性受体之一，并通过凝集素途径负责补体激活，因此在肾脏移植中起着重要作用。

这项研究的目的是检查MBL2基因多态性与同种异体肾的急性排斥反应之间的关系。这项研究招募了266名白种人死者肾移植受者，其中69名被诊断为急性移植排斥反应，197名具有稳定的移植功能。

对来自10号染色体的969 bp DNA片段进行了测序，包括MBL2基因的启动子区和外显子1 。根据NCBI dbSNP数据库，获得的DNA片段含有122个SNP。在这个数字中，只有九个在我们的种群中显示出变异（rs36014597，rs5030737，rs1800450，rs7095891，rs11003123，rs7096206，rs7084554，rs11003124，rs11003125），并且仅对它们进行了进一步分析。

在MBL2基因的多态性研究中，只有rs1800450多态性在统计学上与肾脏同种异体移植排斥显着相关。AA基因型与急性肾移植排斥反应的风险增加显着相关。（AA vs GA + GG：OR = 9.29（95％CI：1.83–47.17），p = 0.005）。

我们的研究结果表明MBL2基因rs1800450多态性可能与急性肾移植排斥反应的风险有关。与较低的MBL2表达相关的AA基因型可能与急性肾移植排斥反应的风险增加有关。