Binding of sperm to egg in the mouse has been proposed to depend primarily on interactions between lectin-like egg-binding proteins on the sperm plasma membrane and complementary carbohydrates on the specialized extracellular matrix of the egg known as the zona pellucida. An alternative model posits that initial sperm-egg binding depends on the interaction of a sperm surface protein with a supramolecular complex of the three mouse zona pellucida glycoproteins (mZP1, mZP2, mZP3); the role of carbohydrate recognition in this paradigm is thought to be minimal (Gahlay G, Gauthier L, Baibakov B, Epifano O,Dean J. 2010. Gamete recognition in mice depends on the cleavage status of an egg's zona pellucida protein. Science.329:216-219). This perspective reviews these recent findings,and considers them in light of evidence favoring a major role for lectin-like interactions. An alternative model, the domain specific model for mammalian gamete binding, could reconcile some of the conflicting observations.

中文翻译：

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小鼠精卵细胞结合的分子模型。

已经提出小鼠中精子与卵的结合主要取决于精子质膜上的凝集素样卵结合蛋白与卵的特殊细胞外基质（称为透明带）上的互补碳水化合物之间的相互作用。一种替代模型认为，最初的精子与卵子结合取决于精子表面蛋白与三种小鼠透明带糖蛋白（mZP1，mZP2，mZP3）的超分子复合物的相互作用。碳水化合物识别在该范例中的作用被认为是微不足道的（Gahlay G，Gauthier L，Baibakov B，Epifano O，Dean J.2010。小鼠中的配子识别取决于蛋的透明带蛋白的裂解状态。Science.329 ：216-219）。这种观点回顾了这些最新发现，并根据有利于凝集素样相互作用的证据来考虑它们。一种替代模型，即哺乳动物配子结合的领域特定模型，可以调和一些相互矛盾的观察结果。