Enteric Campylobacter species cause gastrointestinal diseases in humans. Like almost all organisms, campylobacters have an absolute requirement for iron, but are faced with variable availability of iron in the environment and host tissues. Campylobacters have developed mechanisms to scavenge sufficient iron for metabolism and growth. However, iron also participates in the formation of reactive oxygen species, and this forces pathogens to maintain intracellular iron homeostasis and to cope with oxidative stresses. The presence of two separate, but possibly overlapping iron-responsive regulatory systems, which regulate iron acquisition and oxidative stress defense, and the presence of genes encoding multiple iron acquisition and detoxification systems in Campylobacter indicate the central role that iron plays in Campylobacter gene regulation and virulence.

中文翻译：

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铁在弯曲杆菌基因调节，代谢和氧化应激防御中的作用。

肠弯曲杆菌物种会导致人类胃肠道疾病。像几乎所有生物一样，弯曲杆菌对铁有绝对的需求，但在环境和宿主组织中铁的利用率却不尽相同。弯曲杆菌已开发出清除代谢和生长所需铁的机制。然而，铁还参与了活性氧的形成，这迫使病原体维持细胞内铁的稳态并应对氧化应激。存在两个独立的但可能重叠的铁响应调节系统，它们调节铁的获取和氧化应激防御，