The ability of bacteria to adhere to mucosal epithelium is dependent on the expression of adhesive molecules or structures, called adhesins, that allow attachment of the organisms to complementary molecules on mucosal surfaces, the receptors. Important human and animal pathogens are found among the Pasteurellaceae family which includes Haemophilus, Actinobacillus, and Pasteurella organisms. The purpose of this paper is to review the adhesin-receptor systems found in Pasteurellaceae, with an emphasis on recent developments in this specific area. Most of these organisms can employ multiple molecular mechanisms of adherence (or multiple adhesins) to initiate infection. Indeed, a wide variety of adhesins are expressed by members of the Pasteurellaceae, and different proteins (e.g. fimbriae, fibrils, outer membrane proteins) as well as polysaccharides (lipooligosaccharides, lipopolysaccharides, capsular polysaccharides) were clearly shown to play an important role in adherence. In many instances, these adhesins have proved to represent good vaccine candidates. Surprisingly, the receptors on host mucosal surfaces have yet been identified in very few cases.

中文翻译：

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巴氏杆菌科中的粘附素-受体相互作用。

细菌粘附于粘膜上皮的能力取决于粘附分子或结构（称为粘附素）的表达，该粘附分子或结构使生物体附着于粘膜表面受体上的互补分子。在巴斯德氏菌科中发现了重要的人类和动物病原体，其中包括嗜血杆菌，放线杆菌和巴斯德氏菌。本文的目的是回顾在巴斯德杆菌科中发现的黏附素受体系统，重点是该特定领域的最新发展。这些生物大多数都可以采用多种粘附分子机制（或多种粘附素）来引发感染。实际上，巴斯德氏菌科成员和各种蛋白质（例如，菌毛，原纤维，外膜蛋白）以及多糖（脂寡糖，脂多糖，荚膜多糖）被清楚地证明在黏附中起着重要作用。在许多情况下，这些粘附素已被证明是良好的候选疫苗。令人惊讶的是，在极少数情况下仍未鉴定出宿主粘膜表面的受体。