The initial step of methanogenesis from CO2 is the formation of formyl-methanofuran (formyl-MFR) from methanofuran (MFR), CO2 and H2. The enzymology of this novel type of CO2 fixation reaction has been difficult to study because formyl-MFR synthesis is subject to a complex activation. Recently, however, a number of advances have made questions regarding formyl-MFR synthesis more approachable.

中文翻译：

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热自养甲烷甲烷菌中的甲酰-甲基呋喃合成。

由CO2甲烷化的初始步骤是由甲氧基呋喃（MFR），CO2和H2形成甲酰基-甲基呋喃（甲酰基-MFR）。这种新型的CO2固定反应的酶学已经很难研究，因为甲酰基MFR的合成过程很复杂。然而，近来，许多进展使关于甲酰基-MFR合成的问题更容易解决。