Free-living amoebae feed on bacteria, fungi, and algae. However, some microorganisms have evolved to become resistant to these protists. These amoeba-resistant microorganisms include established pathogens, such as Cryptococcus neoformans, Legionella spp., Chlamydophila pneumoniae, Mycobacterium avium, Listeria monocytogenes, Pseudomonas aeruginosa, and Francisella tularensis, and emerging pathogens, such as Bosea spp., Simkania negevensis, Parachlamydia acanthamoebae, and Legionella-like amoebal pathogens. Some of these amoeba-resistant bacteria (ARB) are lytic for their amoebal host, while others are considered endosymbionts, since a stable host-parasite ratio is maintained. Free-living amoebae represent an important reservoir of ARB and may, while encysted, protect the internalized bacteria from chlorine and other biocides. Free-living amoebae may act as a Trojan horse, bringing hidden ARB within the human "Troy," and may produce vesicles filled with ARB, increasing their transmission potential. Free-living amoebae may also play a role in the selection of virulence traits and in adaptation to survival in macrophages. Thus, intra-amoebal growth was found to enhance virulence, and similar mechanisms seem to be implicated in the survival of ARB in response to both amoebae and macrophages. Moreover, free-living amoebae represent a useful tool for the culture of some intracellular bacteria and new bacterial species that might be potential emerging pathogens.

中文翻译：

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耐自由活动的变形虫的微生物。

自由活动的变形虫以细菌，真菌和藻类为食。但是，一些微生物已经进化成对这些原生生物具有抗性。这些耐变形虫的微生物包括已确定的病原体，例如新隐球菌，军团菌属，肺炎衣原体，鸟分枝杆菌，单核细胞增生李斯特菌，铜绿假单胞菌和土拉弗朗西斯菌，以及新出现的病原体，例如牛sea菌，拟南芥，拟南芥。和军团菌样变形虫病原体。这些抗变形虫细菌（ARB）中的某些可裂解其变形虫宿主，而其他细菌则被视为内共生菌，因为维持了稳定的宿主-寄生虫比率。自由活动的变形虫是ARB的重要储藏库，虽然受其限制，但可以保护内在细菌免受氯和其他杀生物剂的侵害。自由活动的变形虫可以充当特洛伊木马，将隐藏的ARB带入人类“ Troy”，并可能产生充满ARB的囊泡，从而增加其传播潜力。自由活动的变形虫还可能在毒力性状的选择和巨噬细胞的生存适应中发挥作用。因此，发现阿米巴内的生长增强了毒力，并且类似的机制似乎与应对变形虫和巨噬细胞的ARB的存活有关。此外，自由活动的变形虫是培养某些细胞内细菌和可能是潜在新兴病原体的新细菌物种的有用工具。自由活动的变形虫还可能在毒力性状的选择和巨噬细胞的生存适应中发挥作用。因此，发现阿米巴内的生长增强了毒力，并且类似的机制似乎与应对变形虫和巨噬细胞的ARB的存活有关。此外，自由活动的变形虫是培养某些细胞内细菌和可能是潜在新兴病原体的新细菌物种的有用工具。自由活动的变形虫还可能在毒力性状的选择和巨噬细胞的生存适应中发挥作用。因此，发现阿米巴内的生长增强了毒力，并且类似的机制似乎与应对变形虫和巨噬细胞的ARB的存活有关。此外，自由活动的变形虫是培养某些细胞内细菌和可能是潜在新兴病原体的新细菌物种的有用工具。