Despite considerable efforts, malaria is still one of the most devastating infectious diseases in the tropics. The rapid spread of antimalarial drug resistance currently compounds this grim picture. In this paper, we review the history of antimalarial drug resistance and the methods for monitoring it and assess the current magnitude and burden of parasite resistance to two commonly used drugs: chloroquine and sulfadoxine-pyrimethamine. Furthermore, we review the factors involved in the emergence and spread of drug resistance and highlight its public health importance. Finally, we discuss ways of dealing with such a problem by using combination therapy and suggest some of the research themes needing urgent answers.

中文翻译：

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疟疾寄生虫抵抗的历史，动态和公共卫生重要性。

尽管付出了巨大的努力，疟疾仍然是热带地区最严重的传染病之一。目前，抗疟疾药物耐药性的迅速蔓延使这一严峻形势变得更加严峻。在本文中，我们回顾了抗疟药耐药性的历史及其监测方法，并评估了目前对两种常用药物：氯喹和磺胺多辛-乙胺嘧啶的寄生虫耐药性的程度和负担。此外，我们回顾了耐药性的出现和传播所涉及的因素，并强调了其对公共卫生的重要性。最后，我们讨论了使用联合疗法解决此类问题的方法，并提出了一些需要紧急解答的研究主题。