The fitting of mathematical models to physiological sys tems can be tedious and difficult, whether one uses analog or digital computer methods. Both methods have their pros and cons depending on the available hardware and software and on the type of modeling. In recent years many digital simulation languages have been written com bining analog-like and digital features to facilitate model ing, but, for a variety of reasons, none of these was suit able for our applications. We, therefore, designed a new digital simulation control system, SIMCON, which is de scribed in this paper. The primary objectives were to provide: (1) Maximum man-machine interaction at run-time, in cluding visual displays, digital control, and both con tinuous analog and digital parameter adjustment (2) The ability to generate solutions and to fit them to experimental data or other theoretical curves with a minimum of computer memory (3) The option to use a mathematically oriented language, FORTRAN, and block operators with variable input/ output. The result is a relatively general and simple simulation system which is easy to use and has wide versatility.

中文翻译：

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SIMCON——优化人机交互的仿真控制

无论使用模拟还是数字计算机方法，将数学模型拟合到生理系统都可能既乏味又困难。根据可用的硬件和软件以及建模类型，这两种方法各有利弊。近年来，已经编写了许多数字仿真语言，结合类模拟和数字特征以促进建模，但是由于各种原因，这些语言都不适用于我们的应用程序。因此，我们设计了一种新的数字仿真控制系统 SIMCON，在本文中进行了描述。主要目标是提供： (1) 运行时最大程度的人机交互，包括视觉显示、数字控制、以及连续的模拟和数字参数调整 (2) 生成解决方案并将其拟合到实验数据或其他理论曲线的能力，而计算机内存最少 (3) 使用面向数学的语言、FORTRAN 和块的选项具有可变输入/输出的运算符。结果是一个相对通用和简单的仿真系统，它易于使用且具有广泛的通用性。