Aminoglycoside antibiotics have had a major impact on our ability to treat bacterial infections for the past half century. Whereas the interest in these versatile antibiotics continues to be high, their clinical utility has been compromised by widespread instances of resistance. The multitude of mechanisms of resistance is disconcerting but also illuminates how nature can manifest resistance when bacteria are confronted by antibiotics. This article reviews the most recent knowledge about the mechanisms of aminoglycoside action and the mechanisms of resistance to these antibiotics.

中文翻译：

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氨基糖苷的多功能性及其未来前景。

在过去的半个世纪中，氨基糖苷类抗生素对我们治疗细菌感染的能力产生了重大影响。尽管对这些多功能抗生素的兴趣仍然很高，但其临床实用性已受到广泛耐药性的影响。多种耐药机制令人困惑，但也阐明了当细菌面对抗生素时，自然如何表现出耐药性。本文回顾了有关氨基糖苷作用机制和对这些抗生素耐药机制的最新知识。