Attention-deficit hyperactivity disorder (ADHD) is the most common psychiatric disorder in children and adolescents, which is characterized by behavioral problems such as attention deficit, hyperactivity, and impulsivity. As the receptors of the major excitatory neurotransmitter in the mammalian central nervous system (CNS), glutamate receptors (GluRs) are strongly linked to normal brain functioning and pathological processes. Extensive investigations have been made about the structure, function, and regulation of GluR family, describing evidences that support the disruption of these mechanisms in mental disorders, including ADHD. In this review, we briefly described the family and function of GluRs in the CNS, and discussed what is recently known about the role of GluRs in ADHD, that including GluR genes, animal models, and the treatment, which would help us further elucidate the etiology of ADHD.

中文翻译：

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谷氨酸受体在注意力缺陷/多动症中的作用：从生理学到疾病。

注意缺陷多动障碍（ADHD）是儿童和青少年中最常见的精神疾病，其特征在于行为问题，例如注意力不足，多动和冲动。作为哺乳动物中枢神经系统（CNS）中主要的兴奋性神经递质的受体，谷氨酸受体（GluRs）与正常的大脑功能和病理过程密切相关。已经对GluR家族的结构，功能和调节进行了广泛的研究，描述了支持破坏包括ADHD在内的精神障碍中这些机制的证据。在这篇综述中，我们简要描述了GluRs在中枢神经系统中的家族和功能，并讨论了有关GluRs在ADHD中的作用的最新知识，包括GluR基因，动物模型和治疗方法，