Prion diseases are fatal neurodegenerative disorders that affect humans and animals. Although various small molecules have been evaluated for application in the treatment of prion diseases, none have been shown to be efficacious. Expanding our knowledge of these molecules is important for understanding of the complex mechanisms of prion diseases. To improve access to the scattered information on small molecules related to prion diseases, we built a database of therapeutic molecules associated with prion diseases (THERPA, therpa.pythonanywhere.com). THERPA includes 119 small molecules and their 283 relationships with prion diseases. THERPA is an interactive visual database and useful for improving search efficiency which can help researchers identify intrinsic small molecules that can be used for developing therapeutics for prion diseases.

朊病毒病是影响人类和动物的致命性神经退行性疾病。尽管已经评估了各种小分子在朊病毒疾病治疗中的应用，但没有一种小分子被证明是有效的。扩大我们对这些分子的了解对于理解朊病毒疾病的复杂机制非常重要。为了更好地获取与朊病毒疾病相关的小分子的分散信息，我们建立了与朊病毒疾病相关的治疗分子数据库（THERPA，therpa.pythonanywhere.com）。 THERPA 包括 119 个小分子及其与朊病毒疾病的 283 种关系。 THERPA 是一个交互式视觉数据库，可用于提高搜索效率，帮助研究人员识别可用于开发朊病毒疾病疗法的内在小分子。