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Exposure to organic and inorganic traffic-related air pollutants alters haematological and biochemical indices in albino mice Mus musculus.
International Journal of Environmental Health Research ( IF 2.2 ) Pub Date : 2019-02-13 , DOI: 10.1080/09603123.2019.1577367
Azis Kemal Fauzie 1 , G V Venkataramana 1
Affiliation  

The relationship between air pollution exposure and haematology remains controversial. Evidences in the effect of trace organic air pollutants and in the impact of such exposure on lipid and protein levels are scarce. This work investigated the health effects of medium-term exposure to traffic-related air pollution on both haematological and biochemical indices in animal models. Two groups of albino mice (Mus musculus) were exposed to ambient air polluted by vehicle exhaust for three and six months, and one group was kept as control. Results found significant depletions (p < 0.05) in red blood cells, packed cell volume, neutrophils, eosinophils, monocytes, and total cholesterol after air pollution exposure. On the contrary, significant elevations (p < 0.05) were observed in platelet, lymphocytes, and serum albumin compared to control condition. Correlation data suggested that significant changes in blood parameters may be altered by the synergistic effect of several organic and inorganic air pollutants.

中文翻译:

暴露于有机和无机交通相关的空气污染物会改变白化病小鼠的血液学和生化指标。

空气污染暴露与血液学之间的关系仍然存在争议。关于痕量有机空气污染物的影响以及这种接触对脂质和蛋白质水平的影响的证据很少。这项工作调查了中期暴露于交通相关空气污染对动物模型血液学和生化指标的健康影响。将两组白化病小鼠(小家鼠)暴露于受到车辆尾气污染的环境空气中三个月和六个月,并将一组作为对照组。结果发现,暴露于空气污染后,红细胞,密集细胞体积,嗜中性粒细胞,嗜酸性粒细胞,单核细胞和总胆固醇显着减少(p <0.05)。相反,血小板,淋巴细胞,与血清白蛋白相比,控制条件。相关数据表明,几种有机和无机空气污染物的协同作用可能会改变血液参数的重大变化。
更新日期:2020-04-18
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