Diastolic dysfunction causes close to half of congestive heart failures and is associated with increased stiffness in left-ventricular myocardium. A clinical tool capable of measuring viscoelasticity of the myocardium could be beneficial in clinical settings. We used Lamb wave Dispersion Ultrasound Vibrometry (LDUV) for assessing the feasibility of making in vivo non-invasive measurements of myocardial elasticity and viscosity in pigs. In vivo open-chest measurements of myocardial elasticity and viscosity obtained using a Fourier space based analysis of Lamb wave dispersion are reported. The approach was used to perform ECG-gated transthoracic in vivo measurements of group velocity, elasticity and viscosity throughout a single heart cycle. Group velocity, elasticity and viscosity in the frequency range 50-500 Hz increased from diastole to systole, consistent with contraction and relaxation of the myocardium. Systolic group velocity, elasticity and viscosity were 5.0 m/s, 19.1 kPa, 6.8 Pa·s, respectively. In diastole, the measured group velocity, elasticity and viscosity were 1.5 m/s, 5.1 kPa and 3.2 Pa·s, respectively.

中文翻译：

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使用兰姆波色散超声振动测量法 (LDUV) 对左心室心肌粘弹性进行体内开胸和闭胸测量：一项可行性研究。

舒张功能障碍导致近一半的充血性心力衰竭，并与左心室心肌僵硬增加有关。能够测量心肌粘弹性的临床工具在临床环境中可能是有益的。我们使用兰姆波色散超声振动测量法 (LDUV) 来评估对猪的心肌弹性和粘度进行体内非侵入性测量的可行性。报道了使用基于傅立叶空间的兰姆波色散分析获得的心肌弹性和粘度的体内开胸测量。该方法用于在单个心脏周期内对群速度、弹性和粘度进行 ECG 门控经胸体内测量。50-500 Hz 频率范围内的群速度、弹性和粘度从舒张期到收缩期增加，与心肌的收缩和舒张相一致。收缩群速度、弹性和粘度分别为 5.0 m/s、19.1 kPa、6.8 Pa·s。在舒张期，测得的群速度、弹性和粘度分别为 1.5 m/s、5.1 kPa 和 3.2 Pa·s。