GATA3 is a transcription factor involved in the development and differentiation of lymphocytes, breast, and hair follicles. The protein is a useful immunohistochemical (IHC) marker for supporting diagnoses of breast or urothelial carcinoma. This can be especially helpful in metastatic neoplasms to help delineate site of origin. GATA3 is also reportedly positive in a percentage of pancreatic ductal adenocarcinomas (PDACs) and cholangiocarcinomas (CCs), but no study has closely evaluated this relationship with respect to clininopathologic features or patient outcome. Using tissue microarrays, we analyzed 240 PDACs and 60 CCs with GATA3 IHC and compared expression to various clinical and pathologic parameters. Overall, GATA3 positivity was seen in 16% of PDACs and 5% of CCs. GATA3 positivity in PDAC cases was more common in male patients (P=0.013). GATA3-positive PDACs trended toward worse survival on multivariate analysis (P=0.074). The only 3 GATA3-positive CCs were poorly differentiated (P=0.069); low case number precluded multivariate survival analysis for CCs. GATA3 positivity can occur in carcinomas of the pancreatobiliary system, which should be considered during IHC workup of neoplasms of unclear origin. This positivity seems to have minimal relevance to patient outcome.

中文翻译：

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GATA3阳性在胰腺导管腺癌和胆管癌中的发生率和意义

GATA3 是一种转录因子，参与淋巴细胞、乳腺和毛囊的发育和分化。该蛋白质是一种有用的免疫组织化学 (IHC) 标记物，用于支持乳腺癌或尿路上皮癌的诊断。这在转移性肿瘤中特别有用，以帮助描绘起源部位。据报道，GATA3 在一定百分比的胰腺导管腺癌 (PDAC) 和胆管癌 (CC) 中也呈阳性，但没有研究在临床病理学特征或患者结果方面密切评估这种关系。我们使用组织微阵列分析了 240 个 PDAC 和 60 个具有 GATA3 IHC 的 CC，并将表达与各种临床和病理参数进行了比较。总体而言，在 16% 的 PDAC 和 5% 的 CC 中观察到 GATA3 阳性。PDAC 病例中 GATA3 阳性在男性患者中更为常见（P=0.013）。在多变量分析中，GATA3 阳性 PDAC 趋向于较差的存活率（P=0.074）。仅有 3 个 GATA3 阳性 CC 分化差（P=0.069）；低病例数排除了 CC 的多变量生存分析。GATA3 阳性可出现在胰胆系统癌中，在对来源不明的肿瘤进行 IHC 检查时应考虑到这一点。这种积极性似乎与患者结果的相关性很小。