Transposable element (TE) insertions are responsible for a significant fraction of spontaneous germ line mutations reported in inbred mouse strains. This major contribution of TEs to the mutational landscape in mouse contrasts with the situation in human, where their relative contribution as germ line insertional mutagens is much lower. In this focussed review, we provide comprehensive lists of TE-induced mouse mutations, discuss the different TE types involved in these insertional mutations and elaborate on particularly interesting cases. We also discuss differences and similarities between the mutational role of TEs in mice and humans.

中文翻译：

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由于逆转录转座子插入引起的小鼠种系突变。


在近交系小鼠品系中报道的自发种系突变中很大一部分是由转座元件（TE）插入造成的。 TE 对小鼠突变景观的主要贡献与人类的情况形成鲜明对比，在人类中，它们作为种系插入诱变剂的相对贡献要低得多。在这篇重点综述中，我们提供了 TE 诱导的小鼠突变的全面列表，讨论了这些插入突变中涉及的不同 TE 类型，并详细阐述了特别有趣的案例。我们还讨论了 TE 在小鼠和人类中的突变作用之间的差异和相似之处。