The endoplasmic reticulum (ER) is an organelle present in most eukaryotic cells and plays a pivotal role in lipid metabolism. ER dysfunction, specifically ER stress (ERS), is a pathophysiological response involved in lipid metabolism and cardiovascular lesions. Therefore, suppression of ERS may improve lipid metabolic disorders and reduce cardiovascular risk. Herein, we focus on novel breakthroughs regarding the roles of ERS in lipid metabolism and cardiovascular disease (CVD), as well as the internal mechanisms of ERS and its status as a potential therapeutic target. This review highlights recent advances in ERS, the regulation of which might be helpful for both basic research and clinical drug design for lipid metabolic disorders and CVD.

中文翻译：

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快照：脂质代谢和心血管疾病中的内质网应激。

内质网（ER）是存在于大多数真核细胞中的细胞器，在脂质代谢中起关键作用。ER 功能障碍，特别是 ER 应激 (ERS)，是一种涉及脂质代谢和心血管病变的病理生理反应。因此，抑制 ERS ​​可以改善脂质代谢紊乱并降低心血管风险。在此，我们关注关于 ERS ​​在脂质代谢和心血管疾病 (CVD) 中的作用的新突破，以及 ERS ​​的内部机制及其作为潜在治疗靶点的地位。这篇综述重点介绍了 ERS ​​的最新进展，其调控可能有助于脂质代谢紊乱和 CVD 的基础研究和临床药物设计。