The peroxisome proliferator-activated receptor γ (PPARγ) coactivator-1s (PGC-1s) can induce the expression of several downstream genes that play pivotal roles in the regulation of mitochondrial biogenesis and metabolism in the heart. Moreover, PGC-1 signaling pathways have also been reported to play a critical role in cardioprotection. Given the significance of PGC-1 coactivators, we summarize the current literature on the molecular mechanisms and roles of PGC-1s in cardiac metabolism. Thus, in this review, we first introduce the basic knowledge regarding PGC-1 signaling pathways. We then discuss their roles in heart metabolism. Moreover, we describe several significant treatments that target the PGC-1 signaling pathway. This review presents the significant roles of PGC-1s in cardiac metabolism and may contribute to the promotion of PGC-1 signaling pathway as a novel therapeutic target.

中文翻译：

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PGC-1：心脏代谢中的能量调节剂。

过氧化物酶体增殖物激活受体 γ (PPARγ) coactivator-1s (PGC-1s) 可以诱导几种下游基因的表达，这些基因在调节心脏线粒体生物发生和代谢中起关键作用。此外，据报道 PGC-1 信号通路在心脏保护中起关键作用。鉴于 PGC-1 共激活剂的重要性，我们总结了当前有关 PGC-1 在心脏代谢中的分子机制和作用的文献。因此，在这篇综述中，我们首先介绍了有关 PGC-1 信号通路的基础知识。然后我们讨论它们在心脏代谢中的作用。此外，我们描述了几种针对 PGC-1 信号通路的重要治疗方法。