Autophagy is a major intracellular digestion system that delivers cytoplasmic components for degradation and recycling. In this capacity, autophagy plays an important role in maintaining cellular homeostasis by mediating the degradation of cellular macromolecules and dysfunctional organelles and regeneration of nutrients for cell growth. Autophagy is important in innate immunity, as it is responsible for the clearance of various pathogens. Deficiency of intracellular autophagy can result in exaggerated activation of the inflammasome. The latter is an innate immune complex that senses diverse pathogen-associated or danger-associated molecular patterns and activates the expression of inflammatory cytokines. In autophagy-deficient cells, accumulation of damaged organelles, misfolded proteins, and reactive oxygen species contribute to inflammasome activation. The lung is continuously exposed to pathogens from the environment, rendering it vulnerable to infection. The lung innate immune cells act as a crucial initial barrier against the continuous threat from pathogens. In this review, we will summarize recent findings on the regulation of autophagy and its inter-action with innate immunity, focusing on the lung.

中文翻译：

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肺先天免疫中的自噬。

自噬是一种主要的细胞内消化系统，可为降解和再循环提供细胞质成分。在这种能力下，自噬通过介导细胞大分子和功能细胞器的降解以及细胞生长养分的再生，在维持细胞稳态中起着重要作用。自噬在先天免疫中很重要，因为它负责清除各种病原体。细胞内自噬的缺乏会导致炎性体的过度活化。后者是一种先天免疫复合物，可感知多种病原体相关或危险相关分子模式并激活炎症性细胞因子的表达。在自噬缺陷细胞中，受损细胞器的积累，错误折叠的蛋白质，和活性氧有助于炎症小体的活化。肺不断暴露于环境中的病原体，使其容易受到感染。肺先天免疫细胞是抵抗病原体持续威胁的关键初始屏障。在这篇综述中，我们将总结自噬调节及其与先天免疫相互作用的最新发现，重点是肺。