Our understanding of the networks of genes and protein functions involved in Alcohol Use Disorder (AUD) remains incomplete, as do the mechanisms by which these networks lead to AUD phenotypes. The fruit fly (Drosophila melanogaster) is an efficient model for functional and mechanistic characterization of the genes involved in alcohol behavior. The fly offers many advantages as a model organism for investigating the molecular and cellular mechanisms of alcohol-related behaviors, and for understanding the underlying neural circuitry driving behaviors, such as locomotor stimulation, sedation, tolerance, and appetitive (reward) learning and memory. Fly researchers are able to use an extensive variety of tools for functional characterization of gene products. To understand how the fly can guide our understanding of AUD in the era of Big Data we will explore these tools, and review some of the gene networks identified in the fly through their use, including chromatin-remodeling, glial, cellular stress, and innate immunity genes. These networks hold great potential as translational drug targets, making it prudent to conduct further research into how these gene mechanisms are involved in alcohol behavior.

中文翻译：

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“大数据”时代利用黑腹果蝇研究酒精使用障碍。

我们对酒精使用障碍 (AUD) 所涉及的基因和蛋白质功能网络的理解仍然不完整，这些网络导致 AUD 表型的机制也是如此。果蝇（Drosophila melanogaster）是研究酒精行为相关基因功能和机制特征的有效模型。果蝇作为模型生物具有许多优势，可用于研究酒精相关行为的分子和细胞机制，以及了解驱动行为的潜在神经回路，例如运动刺激、镇静、耐受性以及食欲（奖励）学习和记忆。果蝇研究人员能够使用多种工具来表征基因产物的功能。为了了解大数据时代果蝇如何指导我们对 AUD 的理解，我们将探索这些工具，并回顾通过它们的使用在果蝇中发现的一些基因网络，包括染色质重塑、神经胶质、细胞应激和先天基因网络。免疫基因。这些网络作为转化药物靶点具有巨大的潜力，因此需要谨慎地进一步研究这些基因机制如何参与酒精行为。