BACKGROUND The bacteria of the group Borrelia burgdorferi s.l. are the etiological agents of Lyme borreliosis in humans, transmitted by bites of ticks. Improvement of control measures requires a solid framework of the environmental traits driving its prevalence in ticks. METHODS We updated a previous meta-analysis of the reported prevalence of Borrelia burgdorferi s.l. in questing nymphs of Ixodes ricinus with a literature search from January 2010-June 2017. This resulted in 195 new papers providing the prevalence of Bb for 926 geo-referenced records. Previously obtained data (878 records, years 2000-2010) were appended for modelling. The complete dataset contains data from 82,004 questing nymphs, resulting in 558 records of B. afzelii, 404 of B. burgdorferi s.s. (only 80 after the year 2010), 552 of B. garinii, 78 of B. lusitaniae, 61 of B. spielmanii, and 373 of B. valaisiana. We associated the records with explicit coordinates to environmental conditions and to a categorical definition of European landscapes (LANMAP2) looking for a precise definition of the environmental niche of the most reported species of the pathogen, using models based on different classification methods. RESULTS The most commonly reported species are B. afzelii, B. garinii and B. valaisiana largely overlapping across Europe. Prevalence in ticks is associated with portions of the environmental niche. Highest prevalence occurs in areas of 280°-290° (Kelvin) of mean annual temperature experiencing a small amplitude, steady spring slope, together with high mean values and a moderate spring rise of vegetation vigor. Low prevalence occurs in sites with low and a noteworthy annual amplitude of temperature and the Normalized Difference Vegetation Index (colder areas with abrupt annual changes of vegetation). Models based on support vector machines provided a correct classification rate of the habitat and prevalence of 89.5%. These results confirm the association of prevalence of the three most commonly reported species of B. burgdorferi s.l. in Europe to parts of the environmental niche and provide a statistically tractable framework for analyzing trends under scenarios of climate change.

中文翻译：

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对欧洲壁虱中伯氏疏螺旋体分布和患病率的最新荟萃分析。

背景技术伯氏疏螺旋体（Borrelia burgdorferi sl）组的细菌是人类human虫莱姆病的病原体，其通过es叮咬传播。改善控制措施需要一个牢固的环境特征框架，以使其its行流行。方法我们通过2010年1月至2017年6月的文献检索，更新了先前报道的伯氏疏螺旋体在追捧蓖麻若虫中的流行情况的荟萃分析。这产生了195篇新文章，为926个地理参考记录提供了Bb的流行性。 。先前获得的数据（878条记录，2000-2010年）被附加到模型中。完整的数据集包含来自82,004个追寻若虫的数据，产生了558个记录，分别为a.fzelii，B。burgdorferi ss 404（仅在2010年之后为80），B。garinii 552，B.lusitaniae 78，B.61。spielmanii和瓦莱亚种373。我们使用基于不同分类方法的模型，将具有明确坐标的记录与环境条件相关联，并与欧洲景观的分类定义（LANMAP2）关联，以寻找对报告最多的病原体物种的环境生态位的精确定义。结果最常报告的物种是非洲的B. afzelii，B。garinii和B. valaisiana，在欧洲范围内大部分重叠。s虫的流行与环境生态位的某些部分有关。发生率最高的地区是年平均温度在280°-290°（开尔文）的区域，振幅小，春季坡度稳定，平均值高，春季植被活力旺盛。低发生率发生在温度年均幅值低且值得注意的地区以及归一化植被指数（植被急剧变化的冷水地区）。基于支持向量机的模型对生境和患病率的正确分类率为89.5％。这些结果证实了欧洲三种最常报道的B. burgdorferi sl的流行与部分环境生态位的关联，并为统计分析在气候变化情况下的趋势提供了可统计的框架。