Molecular imaging has been widely applied in preclinical research. Among these new molecular imaging modalities, microPET imaging can be utilized as a very powerful tool that can obtain the measurements of multiple biological processes in various organs repeatedly in a same subject. This review discusses how this new approach provides noninvasive biomarker for neurotoxicology research and summarizes microPET findings with multiple radiotracers on the variety of neurotoxicity induced by toxic agents in both the rodent and the nonhuman primate brain.

中文翻译：

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分子成像技术在神经毒理学研究中的应用。

分子成像已广泛应用于临床前研究。在这些新的分子成像方式中，microPET成像可以用作非常强大的工具，可以在同一对象中重复获取各个器官中多个生物过程的测量值。这篇综述讨论了这种新方法如何为神经毒理学研究提供非侵入性生物标志物，并总结了具有多种放射性示踪剂的microPET研究结果，它们揭示了啮齿动物和非人类灵长类动物大脑中有毒物质引起的多种神经毒性。