There are two well-known ultrasonic approaches to extract sets of quantitative parameters: Lizzi–Feleppa (LF) parameters: slope, intercept, and midband; and quantitative ultrasound (QUS)–derived parameters: effective scatterer diameter (ESD) and effective acoustic concentration (EAC). In this study, the relation between the LF and QUS-derived parameters is studied theoretically and experimentally on ex vivo mouse livers. As expected from the theory, LF slope is correlated to ESD ( R 2 = 1 . 00 ), and from experimental data, LF midband is correlated to EAC ( R 2 = 0 . 76 ). However, LF intercept is not correlated to ESD ( R 2 = 0 . 25 ) nor EAC ( R 2 = 0 . 07 ). The unexpected correlation observed between LF slope and EAC ( R 2 = 0 . 94 ) results likely from the high correlation between ESD and EAC due to the inversion process. For a liver fat percentage estimation, an important potential medical application, the parameters presenting the better correlation are EAC ( R 2 = 0 . 78 ) and LF midband ( R 2 = 0 . 70 ).

中文翻译：

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两种定量超声方法的分析


有两种众所周知的超声方法可以提取定量参数集： Lizzi–Feleppa (LF) 参数：斜率、截距和中带；定量超声 (QUS) 衍生参数：有效散射体直径 (ESD) 和有效声浓度 (EAC)。在本研究中，在离体小鼠肝脏上从理论上和实验上研究了 LF 和 QUS 衍生参数之间的关系。正如理论所预期的那样，LF 斜率与 ESD 相关 (R 2 = 1 . 00 )，并且根据实验数据，LF 中带与 EAC 相关 (R 2 = 0 . 76 )。然而，LF 截距与 ESD (R 2 = 0 . 25 ) 和 EAC ( R 2 = 0 . 07 ) 无关。在 LF 斜率和 EAC (R 2 = 0. 94) 之间观察到的意外相关性可能是由于反演过程导致 ESD 和 EAC 之间的高度相关性造成的。对于肝脏脂肪百分比估计（一种重要的潜在医学应用），呈现更好相关性的参数是 EAC (R 2 = 0 . 78 ) 和 LF 中带 (R 2 = 0 . 70 )。