A functional microvascular system is imperative to build and maintain healthy tissue. Impaired microvasculature results in ischemia, thereby limiting the tissue's intrinsic regeneration capacity. Therefore, the ability to regenerate microvascular networks is key to the development of effective cardiovascular therapies. To stimulate the formation of new microvasculature, researchers have focused on fabricating materials that mimic the angiogenic properties of the native extracellular matrix (ECM). Here, we will review biomaterials that seek to imitate the physical cues that are natively provided by the ECM to encourage the formation of microvasculature in engineered constructs and ischemic tissue in the body.

中文翻译：

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模仿血管生成生物材料中 ECM 的物理线索。

功能性微血管系统对于构建和维持健康组织至关重要。微脉管系统受损会导致缺血，从而限制组织的内在再生能力。因此，再生微血管网络的能力是开发有效的心血管疗法的关键。为了刺激新微血管的形成，研究人员专注于制造模仿天然细胞外基质（ECM）血管生成特性的材料。在这里，我们将回顾一些生物材料，这些生物材料试图模仿 ECM 本身提供的物理信号，以促进工程结构和体内缺血组织中微脉管系统的形成。