The mechanism of the mineralization process induced by natural mineralized collagen (MC) has been investigated for decades. The purpose of this study was to investigate the efficacy of self-assembled MC for peri-implant bone defect reconstruction in a mini pig. A standardized peri-implant bone defect model was created using 14 mini pig mandibles. Two materials were evaluated, i.e. a mixture of hydroxyapatite and collagen (Type A, TA), and self-assembled MC (Type B, TB). Bio-Oss (BO) and untreated (blank control, BC) groups were used as controls. After 3- and 6-month healing periods, the mini pigs were sacrificed for histomorphometric and microcomputed tomography analysis. After 3 months of healing, the average alveolar ridge height was 3.27 ± 1.57 mm for group TA, 3.28 ± 2.02 mm for group TB and 3.37 ± 1.09 mm for group BO, while group BC showed the lowest height of 2.68 ± 0.47 mm. After 6 months of healing, the average alveolar ridge height was 2.64 ± 1.13 mm for group TA, 4.31 ± 1.80 mm for group TB and 3.87 ± 1.38 mm for group BO, while group BC showed the lowest height of 2.48 ± 1.80 mm. The experimental groups and control group showed similar bone volume density, bone complexity and histological reaction. The self-assembled MC (Type B) stimulated new bone formation in the reconstruction of deficient alveolar ridges around the dental implant; it also displayed excellent clinical operability compared with bone grafts without collagen.

中文翻译：

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矿化的胶原蛋白骨移植材料在微型猪的种植体周围骨缺损重建中的功效。

天然矿化胶原蛋白（MC）诱导矿化过程的机制已研究了数十年。这项研究的目的是研究自组装MC在小型猪中对种植体周围骨缺损重建的功效。使用14头小猪下颌骨创建了标准化的种植体周围骨缺损模型。评价了两种材料，即羟磷灰石和胶原蛋白的混合物（A型，TA）和自组装MC（B型，TB）。使用Bio-Oss（BO）组和未治疗组（空白对照组，BC）作为对照组。在3个月和6个月的愈合期后，处死小型猪，进行组织形态计量学和计算机断层扫描分析。愈合3个月后，TA组的平均牙槽高度为3.27±1.57 mm，TB组的平均牙槽高度为3.28±2.02 mm，BO组的平均牙槽height高度为3.37±1.09 mm，而BC组的最低高度为2.68±0.47 mm。愈合6个月后，TA组的平均牙槽高度为2.64±1.13 mm，TB组的平均牙槽高度为4.31±1.80 mm，BO组的平均牙槽高度为3.87±1.38 mm，而BC组的最低牙槽高度为2.48±1.80 mm。实验组和对照组的骨体积密度，骨复杂性和组织学反应相似。自组装MC（B型）在牙种植体周围缺牙的牙槽重建中刺激了新的骨形成；与不使用胶原蛋白的骨移植相比，它还具有出色的临床可操作性。而BC组的最低高度为2.48±1.80 mm。实验组和对照组的骨体积密度，骨复杂性和组织学反应相似。自组装MC（B型）在牙种植体周围缺牙的牙槽重建中刺激了新的骨形成；与不使用胶原蛋白的骨移植相比，它还具有出色的临床可操作性。而BC组的最低高度为2.48±1.80 mm。实验组和对照组的骨体积密度，骨复杂性和组织学反应相似。自组装MC（B型）在牙种植体周围缺牙的牙槽重建中刺激了新的骨形成；与不使用胶原蛋白的骨移植相比，它还具有出色的临床可操作性。