Intratumoral heterogeneity (ITH) is a major cause underlying therapeutic difficulty of cancer. Although an understanding of ITH is critically important in order to develop novel therapeutic strategies, experimental models that enable the examination of ITH in a time series are lacking.

中文翻译：

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连续移植的患者来源的异种移植肿瘤的多区域基因组分析。

瘤内异质性（ITH）是癌症治疗困难的​​主要原因。尽管了解 ITH 对于开发新的治疗策略至关重要，但缺乏能够在时间序列中检查 ITH 的实验模型。