We report 2 cases of composite lymphoma comprising mantle cell lymphoma and peripheral T-cell lymphoma, not otherwise specified, a rare association that has only been reported twice in the literature. In case 1, a 64-year-old woman presented with massive splenomegaly and lymphadenopathy. Immunohistochemical studies of the lymph node biopsy suggested the presence of 2 lymphomas, a predominant component of a peripheral T-cell lymphoma, not otherwise specified and an in situ mantle cell neoplasia. These suspicions were confirmed with polymerase chain reaction and fluorescence in situ hybridization studies. In case 2, a 45-year-old man presented with an enlarged right tonsil. Contrary to case 1, the biopsy suggested a predominant infiltration of a classical mantle cell lymphoma and an atypical proliferation of T cells. Biclonality was also confirmed with fluorescence in situ hybridization and molecular techniques. Both cases were treated with an up-front autologous stem cell transplantation after achieving first complete remission, and they remained free of disease for a long period of time.

中文翻译：

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含有套细胞和外周 T 细胞淋巴瘤的复合淋巴瘤，未另作说明

我们报告了 2 例复合淋巴瘤，包括套细胞淋巴瘤和外周 T 细胞淋巴瘤，未另作说明，这是一种罕见的关联，仅在文献中报道过两次。在病例 1 中，一名 64 岁女性因大量脾肿大和淋巴结肿大就诊。淋巴结活检的免疫组织化学研究表明存在 2 种淋巴瘤，这是外周 T 细胞淋巴瘤的主要成分，未另作说明，并且是原位套细胞瘤。这些怀疑通过聚合酶链反应和荧光原位杂交研究得到证实。在病例 2 中，一名 45 岁男性出现右侧扁桃体增大。与病例 1 不同，活检提示典型的套细胞淋巴瘤浸润和 T 细胞的非典型增殖。双克隆性也通过荧光原位杂交和分子技术得到证实。两例患者在首次完全缓解后均接受了前期自体干细胞移植治疗，并且在很长一段时间内都没有疾病。