Small airway hyperresponsiveness is a critical aspect in preschool children with asthmatic symptoms interms of asthma control. The aim of this study was to elucidate the relationship of changes in reactance (Xrs) and resistance (Rrs) of IOS and FEV1 with those in clinical parameters and to determine which IOS parameter is correlated with bronchial hyperresponsiveness before positive clinical endpoints.

中文翻译：

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在学龄前儿童的乙酰甲胆碱挑战试验中，通过脉冲示波法系统早期发现气道阻塞。

小气道高反应性是患有哮喘症状的学龄前儿童控制哮喘的关键方面。这项研究的目的是阐明IOS和FEV1的电抗（Xrs）和耐药性（Rrs）的变化与临床参数的关系，并确定在阳性临床终点之前哪个IOS参数与支气管高反应性相关。