Chronic granulomatous disease (CGD) is a rare primary immunodeficiency caused by defects in the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase enzyme system. This disease causes the disordered functioning of phagocytic cells. It is characterized by life-threatening and/or recurrent infections by bacteria and fungi. CGD has both an X-linked recessive (X-CGD) and autosomal recessive (AR-CGD) phenotypes. AR form have four subtypes including defects with one of these NADPH oxidase components (p22, p40, p47 and p67phox).

中文翻译：

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单中心经验的7例慢性肉芽肿病病例并文献复习。

慢性肉芽肿病（CGD）是由烟酰胺腺嘌呤二核苷酸磷酸（NADPH）氧化酶系统缺陷引起的罕见的原发性免疫缺陷。该疾病引起吞噬细胞功能紊乱。它的特征是细菌和真菌会威胁生命和/或反复感染。CGD具有X连锁隐性（X-CGD）和常染色体隐性（AR-CGD）表型。AR形式具有四个亚型，包括这些NADPH氧化酶成分之一的缺陷（p22，p40，p47和p67phox）。