Pelvic venous congestion (PC) is thought to be related to several diseases of the lower urinary tract (LUT). We examined the characteristics of the LUT in rats with PC. To create PC, female rats were anesthetized with isoflurane, and the bilateral common iliac veins and bilateral uterine veins were ligated. At 1-8 weeks after either ligation or sham surgery, we performed cystometry with or without administration of carbazochrome sodium sulfonate hydrate or propiverine hydrochloride, histologic examination of the bladder, blood flow imaging, assessment of locomotor activity, measurement of urinary 8-hydroxydeoxyguanosine (8-OHdG) and nitric oxide metabolites (NOx), and the Evans blue dye extravasation test. PC elevated frequency of urination after 2-6 weeks, and caused a decrease of spontaneous locomotor activity. In addition, there was a decrease of bladder blood flow, an increase of bladder vascular permeability, an increase of urinary 8-OHdG, a decrease of urinary NOx, and mild inflammatory changes of the bladder. In rats with PC, frequency of urination was normalized by administration of propiverine or carbazochrome. Rats with PC may be used as a model of PC associated with high frequency of urination, and this model may be useful when developing treatment for LUT symptoms associated with PC.

中文翻译：

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骨盆静脉充血可诱发大鼠下尿路功能障碍。

盆腔静脉充血（PC）被认为与下尿路（LUT）的几种疾病有关。我们检查了PC大鼠的LUT的特征。为了制造PC，用异氟烷麻醉雌性大鼠，并结扎双侧common总静脉和双侧子宫静脉。在结扎手术或假手术后1-8周，我们进行了膀胱镜检查，有或没有给予卡巴唑磺酸钠水合物或盐酸丙泊林，对膀胱进行组织学检查，血流显像，运动功能评估，尿中的8-羟基脱氧鸟苷（ 8-OHdG）和一氧化氮代谢物（NOx），以及伊文思蓝染料渗出试验。2-6周后，PC排尿频率升高，并导致自发运动能力降低。此外，膀胱血流量减少，膀胱血管通透性增加，尿中8-OHdG增加，尿中NOx减少，并且膀胱有轻度炎症变化。在患有PC的大鼠中，排尿频率通过服用普罗维林或咔唑铬来正常化。患有PC的大鼠可用作与高尿频相关的PC模型，当开发与PC相关的LUT症状的治疗方法时，该模型可能有用。