Celiac disease is an autoimmune condition triggered by the ingestion of gluten, the protein fraction of wheat, barley and rye. It is not simply an intestinal disease; it is multifactorial caused by many different genetic factors acting together with non-genetic causes. Similar to other autoimmune diseases, celiac disease is a polygenic disorder for which the major histocompatibility complex locus is the most important genetic factor, and is the result of an immune response to self-antigens leading to tissue destruction and the autoantibodies production. Celiac disease exemplifies how an illness can have autoimmune-like features having to be driven by exogenous antigen and how can be reasonably considered as a model of organ-specific autoimmunity.

中文翻译：

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腹腔疾病自身免疫。

乳糜泻是一种自身免疫性疾病，由麸质，小麦，大麦和黑麦的蛋白质组分的摄入引起。它不仅仅是一种肠道疾病；它是由许多不同的遗传因素与非遗传原因共同作用引起的多因素作用。与其他自身免疫性疾病相似，腹腔疾病是一种多基因性疾病，其主要组织相容性复合体位点是最重要的遗传因素，并且是对自身抗原的免疫反应导致组织破坏和自身抗体产生的结果。腹腔疾病举例说明疾病如何具有必须由外源抗原驱动的自身免疫样特征，以及如何合理地认为其是器官特异性自身免疫的模型。