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Effect of Fe3O4 Nanoparticles on Mixed POPC/DPPC Monolayers at Air-Water Interface
Scanning Pub Date : 2019-03-03 , DOI: 10.1155/2019/5712937
Zhuangwei Xu 1 , Changchun Hao 1 , Bin Xie 1 , Runguang Sun 1
Affiliation  

Fe3O4 nanoparticles (NPs) as a commonly used carrier in targeted drug delivery are widely used to carry drugs for the treatment of diseases. However, the mechanism of action of between Fe3O4 NPs and biological membranes is still unclear. Therefore, this article reports the influence of hydrophilic and hydrophobic Fe3O4 NPs on mixed 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) and 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) that were studied using the Langmuir-Blodgett (LB) film technique and an atomic force microscope (AFM). From surface pressure-area (π-A) isotherms, we have calculated the compression modulus. The results showed that hydrophobic Fe3O4 NPs enlarged the liquid-expanded (LE) and liquid-condensed (LC) phase of the mixed POPC/DPPC monolayers. The compressibility modulus of the mixed POPC/DPPC monolayer increases for hydrophilic Fe3O4 NPs, but the opposite happens for the hydrophobic Fe3O4 NPs. The adsorption of hydrophobic Fe3O4 NPs in mixed POPC/DPPC monolayers was much more than the hydrophilic Fe3O4 NPs. The interaction of hydrophilic Fe3O4 NPs with the head polar group of the mixed lipids increased the attraction force among the molecules, while the interaction of hydrophobic Fe3O4 NPs with the tail chain of the mixed lipids enhanced the repulsive force. The morphology of the monolayers was observed by AFM for validating the inferred results. This study is of great help for the application of Fe3O4 NPs in biological systems.

中文翻译:

Fe3O4纳米颗粒对气水界面混合POPC/DPPC单层的影响

Fe3O4 纳米颗粒(NPs)作为靶向药物递送中常用的载体,被广泛用于携带治疗疾病的药物。然而,Fe3O4 NPs 与生物膜之间的作用机制尚不清楚。因此,本文报道了亲水性和疏水性 Fe3O4 NPs 对混合 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) 和 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) 的影响使用 Langmuir-Blodgett (LB) 薄膜技术和原子力显微镜 (AFM) 进行研究。根据表面压力-面积 (π-A) 等温线,我们计算了压缩模量。结果表明,疏水性 Fe3O4 NPs 扩大了混合 POPC/DPPC 单层的液体膨胀 (LE) 和液体冷凝 (LC) 相。亲水性 Fe3O4 NPs 的混合 POPC/DPPC 单层的压缩模量增加,但疏水性 Fe3O4 NPs 发生相反的情况。疏水性 Fe3O4 NPs 在混合的 POPC/DPPC 单层中的吸附比亲水性 Fe3O4 NPs 多得多。亲水性 Fe3O4 NPs 与混合脂质头部极性基团的相互作用增加了分子间的吸引力,而疏水性 Fe3O4 NPs 与混合脂质尾链的相互作用增强了排斥力。通过 AFM 观察单层的形态以验证推断结果。该研究对Fe3O4 NPs在生物系统中的应用有很大帮助。疏水性 Fe3O4 NPs 在混合的 POPC/DPPC 单层中的吸附比亲水性 Fe3O4 NPs 多得多。亲水性 Fe3O4 NPs 与混合脂质头部极性基团的相互作用增加了分子间的吸引力,而疏水性 Fe3O4 NPs 与混合脂质尾链的相互作用增强了排斥力。通过 AFM 观察单层的形态以验证推断结果。该研究对Fe3O4 NPs在生物系统中的应用有很大帮助。疏水性 Fe3O4 NPs 在混合的 POPC/DPPC 单层中的吸附比亲水性 Fe3O4 NPs 多得多。亲水性 Fe3O4 NPs 与混合脂质头部极性基团的相互作用增加了分子间的吸引力,而疏水性 Fe3O4 NPs 与混合脂质尾链的相互作用增强了排斥力。通过 AFM 观察单层的形态以验证推断结果。该研究对Fe3O4 NPs在生物系统中的应用有很大帮助。通过 AFM 观察单层的形态以验证推断结果。该研究对Fe3O4 NPs在生物系统中的应用有很大帮助。通过 AFM 观察单层的形态以验证推断结果。该研究对Fe3O4 NPs在生物系统中的应用有很大帮助。
更新日期:2019-03-03
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