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Anti-oral Microbial Flavanes from Broussonetia papyrifera Under the Guidance of Bioassay.
Natural Products and Bioprospecting ( IF 4.8 ) Pub Date : 2019-01-16 , DOI: 10.1007/s13659-019-0197-y Chang-An Geng 1, 2 , Meng-Hong Yan 1, 2 , Xue-Mei Zhang 1, 2 , Ji-Jun Chen 1, 2, 3
中文翻译：
生物测定指导下构树的抗口腔微生物黄烷。
在生物测定的指导下，从构树的乙酸乙酯部分分离得到1个新的黄烷，即布草醇( 1 )和11个已知的黄烷。化合物1的结构通过广泛的一维和二维核磁共振、[ α ] D光谱数据和量子计算确定。 Daphnegiravan F ( 2 ) 和 5,7,3',4'-四羟基-3-甲氧基-8,5'-二异戊二烯黄酮 ( 3 ) 对 5 种革兰氏阳性菌株和 3 种革兰氏阴性菌株表现出显着的抗口腔微生物活性体外。特别是，化合物3比阳性对照三氯生更有效地抑制内氏放线菌和牙龈卟啉单胞菌(MIC = 1.95 ppm)。
Natural Products and Bioprospecting ( IF 4.8 ) Pub Date : 2019-01-16 , DOI: 10.1007/s13659-019-0197-y Chang-An Geng 1, 2 , Meng-Hong Yan 1, 2 , Xue-Mei Zhang 1, 2 , Ji-Jun Chen 1, 2, 3
Affiliation
Abstract
A new flavane, bropapyriferol (1), and eleven known ones were isolated from the EtOAc part of Broussonetia papyrifera under the guidance of bioassay. The structure of compound 1 was determined by extensive 1D and 2D NMR, [α]D spectroscopic data and quantum computation. Daphnegiravan F (2) and 5,7,3′,4′-tetrahydroxy-3-methoxy-8,5′-diprenylflavone (3) showed significantly anti-oral microbial activity against five Gram-positive strains and three Gram-negative strains in vitro. Especially, compound 3 was more potent in suppressing Actinomyces naeslundii and Porphyromonas gingivalis (MIC = 1.95 ppm) than the positive control, triclosan.Graphical Abstract
中文翻译：
生物测定指导下构树的抗口腔微生物黄烷。
抽象的
在生物测定的指导下，从构树的乙酸乙酯部分分离得到1个新的黄烷，即布草醇( 1 )和11个已知的黄烷。化合物1的结构通过广泛的一维和二维核磁共振、[ α ] D光谱数据和量子计算确定。 Daphnegiravan F ( 2 ) 和 5,7,3',4'-四羟基-3-甲氧基-8,5'-二异戊二烯黄酮 ( 3 ) 对 5 种革兰氏阳性菌株和 3 种革兰氏阴性菌株表现出显着的抗口腔微生物活性体外。特别是，化合物3比阳性对照三氯生更有效地抑制内氏放线菌和牙龈卟啉单胞菌(MIC = 1.95 ppm)。
图解摘要
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