Functional annotation of genomes is a prerequisite for contemporary basic and applied genomic research, yet farmed animal genomics is deficient in such annotation. To address this, the FAANG (Functional Annotation of Animal Genomes) Consortium is producing genome-wide data sets on RNA expression, DNA methylation, and chromatin modification, as well as chromatin accessibility and interactions. In addition to informing our understanding of genome function, including comparative approaches to elucidate constrained sequence or epigenetic elements, these annotation maps will improve the precision and sensitivity of genomic selection for animal improvement. A scientific community-driven effort has already created a coordinated data collection and analysis enterprise crucial for the success of this global effort. Although it is early in this continuing process, functional data have already been produced and application to genetic improvement reported. The functional annotation delivered by the FAANG initiative will add value and utility to the greatly improved genome sequences being established for domesticated animal species.

中文翻译：

---

动物基因组功能注释（FAANG）：最新成果和发展路线图。

基因组的功能注释是当代基础和应用基因组学研究的先决条件，但是养殖动物基因组学在此类注释方面缺乏。为了解决这个问题，FAANG（动物基因组的功能注释）联盟正在生成有关RNA表达，DNA甲基化和染色质修饰以及染色质可及性和相互作用的全基因组数据集。除了告知我们对基因组功能的理解（包括阐明限制序列或表观遗传元素的比较方法）外，这些注释图还将提高基因组选择对动物改良的准确性和敏感性。由科学界推动的努力已经创建了一个协调的数据收集和分析企业，对于这项全球努力的成功至关重要。尽管还处于早期阶段，但已经产生了功能数据，并报道了其在遗传改良中的应用。FAANG计划提供的功能注释将为为驯养的动物物种建立的大大改善的基因组序列增加价值和实用性。