Systemic lupus erythematosus (SLE) is a chronic autoimmune disease linked to profound defects in the function and phenotype of T lymphocytes. Here, we describe abnormal signaling pathways that have been documented in T cells from patients with SLE and discuss how they impact gene expression and immune function, in order to understand how they contribute to disease development and progression.

中文翻译：

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与SLE相关的缺陷可促进T细胞功能的改变。

系统性红斑狼疮（SLE）是一种慢性自身免疫性疾病，与T淋巴细胞的功能和表型严重缺陷有关。在这里，我们描述了SLE患者T细胞中已记录的异常信号通路，并讨论了它们如何影响基因表达和免疫功能，从而了解它们如何促进疾病的发展和进展。