Forkhead box-O (FOXO) transcription factors have a fundamental role in the development and differentiation of immune cells. FOXO1 and FOXO3 are FOXO members that are structurally similar and bind to the same conserved consensus DNA sequences to induce transcription. FOXO1 has been studied in detail in the activation of dendritic cells (DCs), where it plays an important role through the regulation of target genes such as ICAM-1, CCR7, and the integrin αvβ3. FOXO1 is activated by bacteria challenge in DCs and promotes DC bacterial phagocytosis, migration, homing to lymph nodes, DC stimulation of CD4+ T cells and resting B cells, and antibody production. Deletion of FOXO1 in DCs enhances susceptibility to bacteria-induced periodontal disease. FOXO1 and FOXO3 maintain naive T cell quiescence and survival. FOXO1 and FOXO3 enhance the formation of regulatory T cells and inhibit the formation of T-helper 1 (Th1) and Th17 cells. FOXO1 promotes differentiation, proliferation, survival, immunoglobulin gene rearrangement, and class switching in B cells, but FOXO3 has little effect. Both FOXO1 and FOXO3 are important in the maintenance of hematopoietic stem cells by protecting them from oxidative stress. This review examines FOXO1/FOXO3 in the adaptive immune response, key target genes, and FOXO inhibition by the phosphoinositide 3-kinase/AKT pathway.

中文翻译：

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前叉箱1（FOXO1）在免疫系统中的作用：树突状细胞，T细胞，B细胞和造血干细胞。

叉头盒O（FOXO）转录因子在免疫细胞的发育和分化中具有基本作用。FOXO1和FOXO3是FOXO成员，它们在结构上相似，并与相同的保守共有DNA序列结合以诱导转录。FOXO1已在树突状细胞（DC）的激活中进行了详细研究，在FOXO1中它通过调节靶基因如ICAM-1，CCR7和整联蛋白αvβ3发挥重要作用。FOXO1被DC中的细菌攻击激活，并促进DC细菌的吞噬作用，迁移，归巢到淋巴结，CD4 + T细胞和静止B细胞的DC刺激以及抗体产生。DC中FOXO1的删除增强了细菌引起的牙周疾病的敏感性。FOXO1和FOXO3保持幼稚的T细胞静止和存活。FOXO1和FOXO3增强调节性T细胞的形成，并抑制T辅助1（Th1）和Th17细胞的形成。FOXO1促进B细胞的分化，增殖，存活，免疫球蛋白基因重排和类别转换，但FOXO3作用不大。通过保护FOXO1和FOXO3免受氧化应激，它们在维持造血干细胞中很重要。这篇综述研究了磷酸肌醇3-激酶/ AKT途径对FOXO1 / FOXO3的适应性免疫应答，关键靶基因和FOXO抑制作用。通过保护FOXO1和FOXO3免受氧化应激，它们在维持造血干细胞中很重要。这篇综述研究了磷酸肌醇3-激酶/ AKT途径在适应性免疫应答，关键靶基因和FOXO抑制中的FOXO1 / FOXO3。通过保护FOXO1和FOXO3免受氧化应激，它们在维持造血干细胞中很重要。这篇综述研究了磷酸肌醇3-激酶/ AKT途径对FOXO1 / FOXO3的适应性免疫应答，关键靶基因和FOXO抑制作用。