Background: Phototherapy causes oxidative stress which is of particular importance in neonates because of the increased susceptibility of neonatal red blood cell membranes to oxidative damage.Aim: To evaluate the oxidant/antioxidant status in neonates with haemolytic hyperbilirubinaemia before and after exposure to two different intensive phototherapy light sources.Patients and Methods: A randomised controlled study was undertaken in 54 full-term neonates with indirect haemolytic hyperbilirubinaemia admitted to a neonatal intensive care unit in the first week of life. They were randomly divided into two equal groups. Group 1 infants were exposed to intensive conventional phototherapy (Bilisphere 360) and Group 2 were exposed to an intensive light-emitting diode (LED) phototherapy device (Bilitron bed 3600). Total serum bilirubin (TSB), total oxidative stress (TOS), total antioxidant capacity (TAC) and the oxidative stress index (OSI) were measured before and 48 hours after initiation of phototherapy.Results: There was a significant decrease in TSB after phototherapy in both groups (p < 0.001). The TOS and OSI were significantly increased after phototherapy in both groups (p < 0.001) but more so in Group 1 with conventional phototherapy (p = 0.05 and 0.01, respectively). TAC was significantly decreased after phototherapy in both groups (p < 0.00) but more so in Group 1 (p = 0.03).There were significant increases in the incidence of dehydration, hyperthermia and skin rash in the conventional compared with the LED phototherapy group (p = 0.02, 0.01 and 0.02, respectively). However, there was a significant increase in the incidence of hypothermia in the LED compared with the conventional phototherapy group (p = 0.001).Conclusion: Both intensive conventional and LED phototherapy are equally effective in decreasing TSB, but intensive LED phototherapy is safer than intensive conventional phototherapy with regard to oxidative stress and oxidant/antioxidant imbalance.Abbreviations: DSB: direct serum bilirubin; G6PD: glucose-6-phosphate dehydrogenase enzyme; LED: light-emitting diode; OSI: oxidative stress index; TAC: total antioxidant capacity; TOS: total oxidative stresses; TSB: total serum bilirubin.

中文翻译：

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新生儿溶血性高胆红素血症的常规强化与LED强化光疗的氧化应激负担。

背景：光疗会引起氧化应激，这在新生儿中尤为重要，因为新生儿红细胞膜对氧化损伤的敏感性增加。目的：评估暴露于两种不同强化治疗前后的溶血性高胆红素血症新生儿的氧化/抗氧化剂状态患者和方法：对出生后第一周入院的新生儿重症监护病房的54名患有间接溶血性高胆红素血症的足月新生儿进行了一项随机对照研究。他们被随机分为两组。第1组婴儿接受常规常规光疗（Bilisphere 360​​），第2组接受常规发光二极管（LED）光疗设备（Bilitron bed 3600）。总血清胆红素（TSB），在开始光疗之前和之后48小时测量总氧化应激（TOS），总抗氧化能力（TAC）和氧化应激指数（OSI）。结果：两组在光疗后TSB显着降低（p <0.001 ）。两组在光疗后的TOS和OSI均显着升高（p <0.001），而在常规光疗的第1组中则分别升高（p = 0.05和0.01）。两组的TAC均在光疗后显着降低（p <0.00），而在第1组则更为明显（p = 0.03）。与LED光疗组相比，常规方法中脱水，热疗和皮疹的发生率显着增加（ p分别为0.02、0.01和0.02）。然而，与常规光疗组相比，LED体温过低的发生率显着增加（p = 0.001）结论：常规强化和LED光疗均能有效降低TSB，但强化LED光疗比强化常规光疗更安全关于氧化应激和氧化剂/抗氧化剂的不平衡。G6PD：葡萄糖6-磷酸脱氢酶；LED：发光二极管；OSI：氧化应激指数；TAC：总抗氧化能力；TOS：总氧化应激；TSB：总血清胆红素。但就氧化应激和氧化剂/抗氧化剂的不平衡而言，强化的LED光疗比传统的强化光疗更安全。G6PD：葡萄糖6-磷酸脱氢酶；LED：发光二极管；OSI：氧化应激指数；TAC：总抗氧化能力；TOS：总氧化应激；TSB：总血清胆红素。但就氧化应激和氧化剂/抗氧化剂的不平衡而言，强化的LED光疗比传统的强化光疗更安全。G6PD：葡萄糖6-磷酸脱氢酶；LED：发光二极管；OSI：氧化应激指数；TAC：总抗氧化能力；TOS：总氧化应激；TSB：总血清胆红素。