This paper presents a physiological model to reproduce hemodynamic responses to blood volume perturbation. The model consists of three sub-models: a control-theoretic model relating blood volume response to blood volume perturbation; a simple physics-based model relating blood volume to stroke volume and cardiac output; and a phenomenological model relating cardiac output to blood pressure. A unique characteristic of this model is its balance for simplicity and physiological transparency. Initial validity of the model was examined using experimental data collected from 11 animals. The model may serve as a viable basis for the design and evaluation of closed-loop fluid resuscitation controllers.

中文翻译：

---

对血容量扰动的血流动力学反应的面向控制的生理建模

本文提出了一种生理模型来重现对血容量扰动的血流动力学反应。该模型由三个子模型组成：一个将血容量响应与血容量扰动相关联的控制理论模型；一个简单的基于物理学的模型，将血容量与每搏输出量和心输出量联系起来；以及将心输出量与血压联系起来的现象学模型。该模型的一个独特特征是其在简单性和生理透明性方面的平衡。使用从 11 只动物收集的实验数据检查模型的初始有效性。该模型可作为闭环液体复苏控制器设计和评估的可行基础。