Methods for distinguishing catheter-related candidemia (CRC) from non-CRC before catheter removal remain limited. We thus evaluated the diagnostic performance of differential time to positivity (DTP) to diagnose CRC in neutropenic cancer patients with suspected CRC. Of the 35 patients enrolled, 15 (43%) with CRC (six definite and nine probable) and 17 (49%) with non-CRC were finally analyzed. Based on the receiver operating characteristic curve, the optimal cutoff value of DTP for diagnosing CRC was ≥1.45 hours with the sensitivity 80% (95% confidence interval [CI], 51-95) and specificity 100% (95% CI, 80-100), respectively.

中文翻译：

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怀疑导管相关念珠菌血症的中性粒细胞减少癌患者中阳性反应时间差异的诊断价值。

区分导管相关念珠菌血症（CRC）与非CRC的方法仍然很有限。因此，我们评估了差异阳性时间（DTP）对可疑CRC的中性粒细胞癌患者进行CRC诊断的诊断性能。在入选的35例患者中，最终分析了15例（43％）CRC（六个确定性和九个可能性）和17例（49％）非CRC。根据接收器的工作特性曲线，诊断CRC的DTP最佳截止值为≥1.45小时，灵敏度为80％（95％置信区间[CI]，51-95），特异性为100％（95％CI，80- 100）。