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Executive summary of the consensus document of the Spanish Society of Infectious Diseases and Clinical Microbiology (SEIMC), the Spanish Network for Research in Infectious Diseases (REIPI) and the Spanish Society of Haematology and Haemotherapy (SEHH) on the management of febrile neutropenia in patients with hematological malignancies.
Enfermedades Infecciosas y Microbiología Clínica ( IF 2.6 ) Pub Date : 2019-03-27 , DOI: 10.1016/j.eimc.2019.01.013
Carlota Gudiol 1 , Manuela Aguilar-Guisado 2 , José Ramón Azanza 3 , Francisco Javier Candel 4 , Rafael Cantón 5 , Jordi Carratalà 1 , Carolina Garcia-Vidal 6 , Isidro Jarque 7 , Manuel Lizasoain 8 , José Molina Gil-Bermejo 2 , Isabel Ruiz-Camps 9 , Isabel Sánchez-Ortega 10 , Carlos Solano 11 , María Suárez-Lledó 12 , Lourdes Vázquez 13 , Rafael de la Cámara 14
Affiliation  

Febrile neutropenia is a very common complication in patients with hematological malignancies receiving chemotherapy, and is associated with high morbidity and mortality. Infections caused by multidrug-resistant bacteria have become a therapeutic challenge in this high-risk patient population, since inadequate initial empirical treatment can seriously compromise prognosis. However, reducing antimicrobial exposure is one of the most significant cornerstones in the fight against resistance. The objective of these new guidelines is to update recommendations for the initial management of hematological patients who develop febrile neutropenia in this scenario of multidrug resistance. The two participating Societies (the Sociedad Española de Enfermedades Infecciosas y Microbiología Clínica [Spanish Society of Infectious Diseases and Clinical Microbiology] and the Sociedad Española de Hematología y Hemoterapia [Spanish Society of Haematology and Haemotherapy]), designated a panel of experts in the field to provide evidence-based recommendations in response to common clinical questions. This document is primarily focused on bacterial infections. Other aspects related to opportunistic infections, such as those caused by fungi or other microorganisms, especially in hematopoietic stem cell transplantation, are also touched upon.

中文翻译:

西班牙传染病和临床微生物学会 (SEIMC)、西班牙传染病研究网络 (REIPI) 和西班牙血液学和血液疗法协会 (SEHH) 关于患者发热性中性粒细胞减少症管理的共识文件的执行摘要与血液系统恶性肿瘤。

发热性中性粒细胞减少症是接受化疗的血液系统恶性肿瘤患者非常常见的并发症,并且与高发病率和死亡率相关。由多重耐药菌引起的感染已成为这一高危患者群体的治疗挑战,因为初始经验性治疗不充分会严重影响预后。然而,减少抗生素暴露是抗击耐药性的最重要基石之一。这些新指南的目的是更新在这种多药耐药情况下出现发热性中性粒细胞减少症的血液病患者的初始管理建议。两个参与的学会(Sociedad Española de Enfermedades Infecciosas y Microbilogía Clínica [西班牙传染病和临床微生物学会] 和 Sociedad Española de Hematología y Hemoterapia [西班牙血液学和指定的血液疗法领域专家小组])针对常见的临床问题提供循证建议。本文件主要关注细菌感染。与机会性感染相关的其他方面,例如由真菌或其他微生物引起的感染,特别是在造血干细胞移植中,也涉及到。指定了一个该领域的专家小组,以针对常见的临床问题提供基于证据的建议。本文件主要关注细菌感染。与机会性感染相关的其他方面,例如由真菌或其他微生物引起的感染,特别是在造血干细胞移植中,也涉及到。指定了一个该领域的专家小组,以针对常见的临床问题提供基于证据的建议。本文件主要关注细菌感染。与机会性感染相关的其他方面,例如由真菌或其他微生物引起的感染,特别是在造血干细胞移植中,也涉及到。
更新日期:2020-04-14
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