BACKGROUND We analyzed cardiovascular inflammatory (C-reactive protein (CRP), interleukin 6 (IL-6)), haemostatic (homocysteine) risk markers in lean and obese patients at admission and acute hyperglicemic crisis (AHC) resolving, involving diabetic ketoacidosis (DKA) and hyperosmolar hyperglycemic state (HHS). METHODS In that context, we included group A: N = 20 obese, B: N=20 lean patients with DKA; C: N = l0 obese, D: N=10 lean patients with HHS; E: N = 15 obese, F: N=15 lean controls. CRP IL-6, homocysteine were determined by ELISA. RESULTS Our results showed that CRP IL-6, and homocysteine levels decreased in all groups: (A: p<0.001; B: p<0.001, C: p<0.05; D: p<0.001 mg/L), (A: p<0.001 B: p<0.001, C: p<0.001, D: p<0.01 pg/mL), (A: p<0.001, B: p <0.001; C: p<0.05, D: p=0.001 μmol/L), respectively, at resolving AHC. However, CRP persisted higher (p<0.001, p<0.01), IL-6 lower (p<0.05, p<0.001), while homocysteine levels turned out to be similar to controls. CONCLUSIONS AHC is associated with increased inflammatory and hemostatic cardiovascular risk markers. Also, insulin therapy in AHC has had more pronounced favorable effect on IL-6 and homocystein than on CRP.

中文翻译：

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1 型和 2 型糖尿病急性高血糖危象期间的炎症和止血心血管风险标志物。


背景我们分析了瘦和肥胖患者入院时的心血管炎症（C反应蛋白（CRP）、白介素6（IL-6））、止血（同型半胱氨酸）风险标志物以及急性高血糖危象（AHC）解决情况，包括糖尿病酮症酸中毒（DKA） ）和高渗高血糖状态（HHS）。方法 在这种情况下，我们纳入了 A 组：N = 20 名肥胖患者，B 组：N = 20 名瘦弱 DKA 患者； C：N=l0 肥胖，D：N=10 瘦 HHS 患者； E：N = 15 肥胖对照，F：N = 15 瘦对照。通过ELISA测定CRP、IL-6、同型半胱氨酸。结果 我们的结果显示，所有组中的 CRP IL-6 和同型半胱氨酸水平均下降：（A：p<0.001；B：p<0.001；C：p<0.05；D：p<0.001毫克/升), (A: p<0.001 B: p<0.001, C: p<0.001, D: p<0.01 pg/mL), (A: p<0.001, B：p <0.001；C：p<0.05，D：p=0.001 μmol/L），分别在解析 AHC 时。然而，CRP 持续较高（p<0.001，p<0.01），IL-6 较低（p<0.05，p<0.001），而同型半胱氨酸水平与对照组相似。结论 AHC 与炎症和止血性心血管风险标志物增加相关。此外，AHC 中的胰岛素治疗对 IL-6 和同型半胱氨酸的影响比对 CRP 的影响更明显。