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A use/disuse paradigm for CRISPR-Cas systems
Biology & Philosophy ( IF 1.7 ) Pub Date : 2019-02-01 , DOI: 10.1007/s10539-018-9661-z
Sophie Juliane Veigl 1
Affiliation  

In his insightful review, Eugene V. Koonin discusses various aspects of CRISPR-Cas systems with a strong focus on their qualities as "adaptive (acquired) immune systems"(Koonin 2018, 3). The CRISPR-Cas system is most famous for its application as a gene-editing tool. Koonin provides a deeper insight into its biological function in bacteria, which is to immunize the cell against parasite DNA. I shall comment on one issue discussed in the text, in two steps. First, I shall elaborate on CRISPR-Cas systems and their supposed Lamarckian character. Criteria for calling biological phenomena genuinely Lamarckian will be narrowed down and then applied to the CRISPR-Cas system, considering interference-driven spacer acquisition (IDSA) as an instantiation of a truly Lamarckian paradigm. Second, I shall consider whether Lamarckian and "canonical" instances of inheritance are a case of theoretical pluralism, being two non-reducible, yet interconnected paradigms.

中文翻译:

CRISPR-Cas 系统的使用/废弃范例

在他富有洞察力的评论中,Eugene V. Koonin 讨论了 CRISPR-Cas 系统的各个方面,重点关注其作为“适应性(获得性)免疫系统”的品质(Koonin 2018,3)。CRISPR-Cas系统以其作为基因编辑工具的应用而闻名。Koonin 提供了对其在细菌中的生物学功能的更深入的了解,即使细胞对寄生虫 DNA 产生免疫。我将分两步对文中讨论的一个问题进行评论。首先,我将详细阐述 CRISPR-Cas 系统及其假定的拉马克特征。将干扰驱动的间隔区获取 (IDSA) 视为真正拉马克范式的实例,将缩小称为真正拉马克范式的生物现象的标准,然后应用于 CRISPR-Cas 系统。其次,我将考虑拉马克的继承实例和“规范”继承实例是否是理论多元主义的一个例子,是两个不可简化但相互关联的范式。
更新日期:2019-02-01
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