Herein, a facile strategy was firstly developed to synthesize ellipsoidal mesoporous silica nanomaterials (MSNs) with well-ordered parallel channels along the short axis. A miniaturized microfluidic device with spiral-shaped channels was then chosen as a straightforward and general platform to produce the corresponding hollow counterparts of MSNs under mild conditions. Such reaction process carried out in a microfluidic system was further demonstrated to be more rapid and efficient than a conventional batch method under equivalent experimental conditions. The evolution of hollow structure can be well tuned by flow rates (i.e. etching time), providing a new paradigm for rational design and engineering of anisotropic nanostructures.

在此，首先开发了一种简便的策略来合成具有沿短轴的有序平行通道的椭圆形介孔二氧化硅纳米材料（MSN）。然后选择具有螺旋形通道的微型化微流控设备作为直接的通用平台，以在温和条件下生产相应的MSN空心对应物。在同等的实验条件下，与常规的间歇方法相比，在微流体系统中进行的这种反应过程被进一步证明是更加快速和有效的。中空结构的演变可以通过流速（即蚀刻时间）很好地调节，为各向异性纳米结构的合理设计和工程化提供了新的范例。