Recent studies using animal models have generated profound insight into the functions of various subsets of innate lymphoid cells (ILCs). The group 2 ILC subset (ILC2) has been implicated in tissue homeostasis, defense responses against parasites, tissue repair, and immunopathology associated with type-2 immunity. In addition, progress has also been made in translating these findings from animal studies into a context of human immunity. Importantly, recent observations strongly support a role for ILC2s in several diseases of the human respiratory system. However, many aspects of human ILC2 biology are still unclear, including how these cells develop and which signals control their activity. As a result, the exact role played by ILCs in human health and disease remains poorly understood. Here, we summarize our current understanding of human ILC2 biology and focus on their potential involvement in various human respiratory disorders.

中文翻译：

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人类呼吸系统疾病中的第2组先天淋巴样细胞。

最近使用动物模型进行的研究对先天淋巴样细胞（ILC）的各种子集的功能产生了深刻的见解。第2组ILC子集（ILC2）与组织动态平衡，针对寄生虫的防御反应，组织修复以及与2型免疫相关的免疫病理学有关。此外，在将动物研究中的这些发现转化为人类免疫方面也取得了进展。重要的是，最近的观察结果强烈支持ILC2在人类呼吸系统的几种疾病中的作用。但是，人类ILC2生物学的许多方面仍不清楚，包括这些细胞如何发育以及哪些信号控制其活性。结果，人们对ILC在人类健康和疾病中所起的确切作用仍然知之甚少。这里，