Background

Behçet’s disease is a multisystem disease. It stands at the crossroad between the autoimmunity and auto-inflammatory disorders. In this study, we sought to address a relationship that might exist between interleukin-1β (IL-1β) and the oxidants/antioxidants markers in Behçet’s patients.

Methods

Behçet’s disease patients (n = 78: active stage, n = 28; inactive stage, n = 50) and 41 healthy controls have been included in our study. In this context, we investigated the plasma levels of IL-1β and the nitrosative/oxidative markers: nitric oxide (NO), advanced oxidative protein products (AOPP) and fatty acids peroxidation-malondialdehyde (MDA). The antioxidant system was assessed by measuring the plasma level of superoxide dismutase (SOD) activity. The Mann-Whitney’s U and Pearson’s correlation tests were used for statistical analyses.

Results

Our case-control study showed that patients in active stage displayed higher plasma levels of IL-1β, NO, AOPP and MDA versus healthy controls and patients in inactive stage. Patients in active stage showed significantly lower SOD levels related to patients in inactive stage and healthy controls respectively, whereas patients in inactive stage showed statistically insignificant SOD level versus healthy controls. Correlation studies showed a significant positive correlation between IL-1β and AOPP, IL-1β and NO, and negative correlation between IL-1β and SOD among Behçet’s disease patients. In addition, we showed positive correlation between AOPP and NO, AOPP and MDA and negative correlation between NO and SOD, AOPP and SOD in Behçet’s disease patients.

Conclusion

Interestingly, our study revealed that IL-1β levels increased and correlated with an imbalance of oxidants/antioxidants system, especially during active stage of Behçet disease. Collectively, our study indicates a possible link between IL-1β production and nitrosative/oxidative markers during Behçet’s disease. Exploiting this relationship might provide valuable outputs in the follow-up and prognosis of Behçet’s disease with a potential therapeutic value.

中文翻译：

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IL-1β水平升高与贝塞特氏病期间“氧化剂/抗氧化剂”状态失衡有关。

背景

白塞氏病是一种多系统疾病。它处于自身免疫性疾病和自身炎症性疾病之间的十字路口。在这项研究中，我们试图解决白塞病患者白细胞介素-1β（IL-1β）与氧化剂/抗氧化剂标记之间可能存在的关系。

方法

白塞特病患者（n = 78：活动期，n = 28；非活动期，n = 50）和41名健康对照纳入我们的研究。在这种情况下，我们研究了血浆中IL-1β的水平以及亚硝化/氧化标记物：一氧化氮（NO），高级氧化蛋白产物（AOPP）和脂肪酸过氧化丙二醛（MDA）。通过测量血浆超氧化物歧化酶（SOD）活性来评估抗氧化剂系统。使用Mann-Whitney的U和Pearson的相关检验进行统计分析。

结果

我们的病例对照研究表明，处于活动期的患者血浆水平的IL-1β，NO，AOPP和MDA高于健康对照组和处于非活动期的患者。处于活动状态的患者与处于活动状态的患者和健康对照组相比，其SOD水平显着降低，而处于非活动状态的患者与健康对照组相比，SOD水平在统计学上不显着。相关性研究显示，白塞病患者中IL-1β和AOPP，IL-1β和NO之间呈显着正相关，而IL-1β和SOD之间呈负相关。此外，我们发现白塞病患者的AOPP与NO，AOPP和MDA之间呈正相关，与NO，SOD，AOPP和SOD之间呈负相关。

结论

有趣的是，我们的研究表明，IL-1β水平升高并且与氧化剂/抗氧化剂系统的失衡相关，尤其是在Behçet疾病活跃期。总体而言，我们的研究表明在白塞病期间，IL-1β的产生与亚硝化/氧化标记之间可能存在联系。利用这种关系可能会为Behçet病的随访和预后提供有价值的成果，具有潜在的治疗价值。