We re-examined the database of some 20,000 electron micrographs from the Echigo-1, the 263K-strain or the 22C-H of scrapie-infected hamsters to look for the cytoplasmic clearance. We reevaluated the largest database in the world of photographed dystrophic neurites for the presence of cytoplasmic clearance as shown in transgenic fruit flies transfected with A-42. In several neurites, we found electron-lucent areas not bound by any membranes or only partially bound; thus, they were not autophagic vacuoles as the latter are membrane-bound and contain cargo. Those changes were not observed in every examined neurite and no correlation with any other changes were noticed. In some neurites, which could be traced over several sections, the electron-lucent areas were evident to change size, i.e. to expand.

中文翻译：

---

累积自噬泡的营养不良性神经突显示神经破坏的早期阶段。

我们从Echigo-1、263K菌株或22C-H的瘙痒病感染的仓鼠中重新检查了大约20,000张电子显微照片的数据库，以寻找细胞质清除率。我们重新评估了世界上拍摄的营养不良性神经突的最大数据库中是否存在细胞质清除，如转染A-42的转基因果蝇中所示。在几个神经突中，我们发现电子透明区域没有被任何膜束缚或仅被部分束缚。因此，它们不是自噬空泡，因为后者是膜结合的并包含货物。在每个检查的神经突中均未观察到这些变化，也未发现与任何其他变化的相关性。在一些可以在几个截面上找到的神经突中，电子透明区域明显改变了大小，即扩大了。