Bone disorders and disturbed calcium (Ca) homeostasis are common disorders in β-thalassaemia major (β-TM). In the present study, two bone related markers are studied in β-TM patients with negative C-reactive protein for the first time; fibroblast growth factor receptor 2 (FGFR2) and CAPS protein. Another goal is to estimate the correlation between the recent parameters and bone biomaterials as a function of iron status parameters in β-TM patients. The results revealed that, in patients with β-TM serum FGFR2, CAPS, alkaline phosphatase (ALP) and Mg significantly increased while serum Ca levels were low as compared with controls. Ca status is correlated with iron overload in β-TM. A significant correlation was present between CAPS and FGFR2. In conclusion, FGFR2 and CAPS associated with Ca status and subsequent bone disturbances in β-TM patients. Their level can be predicted from the equation: CAPS =0.001ALP +0.48FGFR2-1.26Ca – 3.95Pi +12.76 with acceptable applicability.

骨骼疾病和钙（Ca）稳态紊乱是重度β地中海贫血（β-TM）的常见疾病。在本研究中，首次在具有C反应蛋白阴性的β-TM患者中研究了两种与骨相关的标记物。成纤维细胞生长因子受体2（FGFR2）和CAPS蛋白。另一个目标是根据β-TM患者的铁状态参数，估计近期参数与骨骼生物材料之间的相关性。结果显示，与对照组相比，β-TM血清FGFR2患者的CAPS，碱性磷酸酶（ALP）和Mg显着升高，而血清Ca水平较低。Ca状态与β-TM中铁超载相关。CAPS和FGFR2之间存在显着相关性。总之，FGFR2和CAPS与β-TM患者的钙状态及随后的骨异常有关。