Background: The aim of this study is to assess the impact of baseline quality of life status (as assessed by the EQ-5D-3L questionnaire) on the prognosis of patients with advanced gastric cancer.Methods: This study represents a pooled analysis from the control arms of two clinical trials (NCT00290966; NCT00678535). Both control arms evaluated fluoropyrimidine/cisplatin combination in the first line treatment of advanced gastric cancer. Univariate and multivariate Cox regression analyses were performed to assess factors affecting overall and progression-free survival. Factors with P < 0.05 in univariate analysis were included in the multivariate analysis.Results: A total of 654 patients with advanced gastric cancer were evaluated in the current study. Cox regression analyses were conducted to determine factors which might affect overall and progression-free survival. The following factors were predictive of better overall survival in a multivariate Cox regression model: lower ECOG score (P = 0.031) and higher EQ-5D score (P = 0.001). Likewise, the following factors were predictive of better progression-free survival in a multivariate Cox regression model: lower ECOG score (P = 0.005) and higher EQ-5D score (P = 0.041).Conclusion: Advanced gastric cancer patients with better baseline quality of life status have better overall and progression-free survival. Given the EQ-5D easy-to-use model, extending its use in routine clinical practice settings should be considered.

中文翻译：

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基线胃质量状况对晚期胃癌患者的预后影响；两项随机研究的结果。

背景：本研究的目的是评估基线生活质量状态（通过EQ-5D-3L调查问卷评估）对晚期胃癌患者预后的影响。两项临床试验的对照组（NCT00290966; NCT00678535）。两个对照组均在晚期胃癌的一线治疗中评估了氟嘧啶/顺铂的组合。进行单因素和多因素Cox回归分析以评估影响总体生存和无进展生存的因素。多因素分析包括单因素分析中P <0.05的因素。结果：本研究共评估了654例晚期胃癌患者。进行了Cox回归分析以确定可能影响总体生存和无进展生存的因素。以下因素可预测多变量Cox回归模型中的总体生存情况更好：较低的ECOG评分（P = 0.031）和较高的EQ-5D评分（P = 0.001）。同样，以下因素可预测多变量Cox回归模型中的无进展生存期更好：较低的ECOG评分（P = 0.005）和较高的EQ-5D评分（P = 0.041）。结论：基线质量较好的晚期胃癌患者生命状态的患者具有更好的总体生存率和无进展生存率。鉴于EQ-5D易于使用的模型，应考虑在常规临床实践环境中扩展其使用范围。ECOG得分较低（P = 0.031）和EQ-5D得分较高（P = 0.001）。同样，以下因素可预测多变量Cox回归模型中的无进展生存期更好：较低的ECOG评分（P = 0.005）和较高的EQ-5D评分（P = 0.041）。结论：基线质量较好的晚期胃癌患者生命状态的患者具有更好的总体生存率和无进展生存率。鉴于EQ-5D易于使用的模型，应考虑在常规临床实践环境中扩展其使用范围。ECOG得分较低（P = 0.031）和EQ-5D得分较高（P = 0.001）。同样，以下因素可预测多变量Cox回归模型中的无进展生存期更好：较低的ECOG评分（P = 0.005）和较高的EQ-5D评分（P = 0.041）。结论：基线质量较好的晚期胃癌患者生命状态的患者具有更好的总体生存率和无进展生存率。鉴于EQ-5D易于使用的模型，应考虑在常规临床实践环境中扩展其使用范围。基线生活质量较好的晚期胃癌患者的总体生存率和无进展生存率更高。鉴于EQ-5D易于使用的模型，应考虑在常规临床实践环境中扩展其使用范围。基线生活质量较好的晚期胃癌患者的总体生存率和无进展生存率更高。鉴于EQ-5D易于使用的模型，应考虑在常规临床实践环境中扩展其使用范围。