In this study, we aimed at assessing the therapeutical potential of 6-gingerol ([5S]-5-hydroxy-1-[4-hydroxy- 3-methoxyphenyl]-3-decanone) against ovalbumin-sensitized asthma in rats. The rats were treated intraperitoneally with 6-gingerol (75 mg/kg body weight) for 30 days and a theophylline (200 mg/kg body weight)-treated group as a control. Changes in the levels of T-cell-linked cytokines (interleukin-4 [IL-4], IL-5, IL-13, and interferon-gamma [IFN-?]), total immunoglobulin E (IgE), gene expressions of bitter taste-sensing type 2-receptor 10 (T2R10), inositol 1,4,5-triphosphate receptor 1 (IP3R1), Orai1 and protein expressions of nuclear factor of activated T cells 1 (NFAT1), c-Myc and histopathological changes were observed in rats. 6-Gingerol exerts its beneficial impacts like theophylline in lessening IL-4, IL-5, and IL-13, and IgE and increasing the level of IFN-?. Significant down-regulation of T2R10 gene expression and up-regulation of IP3R1 and Orai1 gene expression were observed in experimental rats and these alterations were normalized after treatment with 6-gingerol or theophylline. The histopathological study revealed that the accumulation of glycoprotein and thickness of alveolar epithelium in asthmatic rats and supplementation with 6-gingerol or theophylline in asthmatic rats restored these changes to normal. In conclusion, 6-gingerol has a protective effect on lungs in ovalbumin-sensitized asthma in rats.

中文翻译：

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减轻6-姜油的哮喘的潜力：对卵清蛋白致敏的大鼠的细胞因子，相关mRNA和c-Myc以及NFAT1表达的影响。

在这项研究中，我们旨在评估6-甘油（[5S] -5-羟基-1- [4-羟基-3-甲氧基苯基] -3-癸酮）对卵白蛋白致敏哮喘的治疗潜力。用6-姜油素（75mg / kg体重）腹膜内处理大鼠30天，并以茶碱（200mg / kg体重）处理组作为对照组。T细胞连接的细胞因子（白介素4 [IL-4]，IL-5，IL-13和干扰素-γ[IFN-γ]），总免疫球蛋白E（IgE），基因表达的水平变化苦味感知型2受体10（T2R10），肌醇1,4,5-三磷酸受体1（IP3R1），Orai1和活化T细胞1（NFAT1），c-Myc的核因子蛋白表达及组织病理学改变在大鼠中观察到。6-姜油在减少IL-4，IL-5和IL-13方面发挥茶碱等有益作用，和IgE并增加IFN-α的水平。在实验大鼠中观察到T2R10基因表达的显着下调以及IP3R1和Orai1基因表达的上调，并且这些改变在用6-姜油醇或茶碱治疗后得以正常化。组织病理学研究表明，哮喘大鼠糖蛋白的积聚和肺泡上皮厚度的增加以及哮喘大鼠补充6-姜油醇或茶碱可将这些变化恢复到正常水平。总之，在大鼠卵白蛋白致敏的哮喘中，6-姜油醇对肺具有保护作用。组织病理学研究表明，哮喘大鼠糖蛋白的积聚和肺泡上皮厚度的增加以及哮喘大鼠补充6-姜油醇或茶碱可将这些变化恢复到正常水平。总之，在大鼠卵白蛋白致敏的哮喘中，6-姜油醇对肺具有保护作用。组织病理学研究表明，哮喘大鼠糖蛋白的积聚和肺泡上皮厚度的增加以及哮喘大鼠补充6-姜油醇或茶碱可将这些变化恢复到正常水平。总之，在大鼠卵白蛋白致敏的哮喘中，6-姜油醇对肺具有保护作用。