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Metabolic and Endocrine Role of Adipose Tissue During Lactation.
Annual Review of Animal Biosciences ( IF 8.7 ) Pub Date : 2017-12-02 , DOI: 10.1146/annurev-animal-030117-014720
J P McNamara 1, 2 , K Huber 3
Affiliation  

The adipose tissue serves an essential role for survival and reproduction in mammals, especially females. It serves primarily as an energy storage organ and is directly linked to the reproductive success of mammals. In wild animals, adipose tissue function is linked to seasonality of the food supply to support fetal growth and milk production. Adipose tissue depots in ruminants and non-ruminants can secrete many signal molecules (adipokines) that act as hormones and as pro- and anti-inflammatory cytokines. The visceral adipose tissue especially appears to be more endocrinologically active than other adipose depots. The endocrine function is important for the overall long-term regulation of energy metabolism and plays an important role in the adaptation to lactation in many mammalian species, including humans. Furthermore, endocrine signals from adipose tissue depots contribute to fertility modulation, immune function, and inflammatory response. Energy homeostasis is modulated by changes in feed intake, insulin sensitivity, and energy expenditure, processes that can be influenced by adipokines in the brain and in peripheral tissues.

中文翻译:

泌乳过程中脂肪组织的代谢和内分泌作用。

脂肪组织对于哺乳动物,尤其是雌性动物的存活和繁殖起着至关重要的作用。它主要用作能量储存器官,与哺乳动物的生殖成功直接相关。在野生动物中,脂肪组织的功能与食物供应的季节性有关,以支持胎儿的生长和产奶。反刍动物和非反刍动物的脂肪组织长处可以分泌许多信号分子(adipokines),它们起着激素以及促炎和消炎细胞因子的作用。内脏脂肪组织尤其比其他脂肪贮库具有更高的内分泌活性。内分泌功能对于能量代谢的整体长期调节很重要,并且在包括人类在内的许多哺乳动物物种的泌乳适应中起着重要作用。此外,来自脂肪组织贮库的内分泌信号有助于调节生育力,免疫功能和炎症反应。能量稳态由饲料摄入,胰岛素敏感性和能量消耗的变化调节,这些过程可能受大脑和周围组织中脂肪因子的影响。
更新日期:2019-11-01
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